TABLE OF CONTENTS (The Second Part)

   The First Part

Chapter 1

COMMON CLINICAL VIEW ON IMMUNITY

1.1

MAJOR NOTIONS

1.1.1

Interview with a patient

1.1.2

Basic clinical skills

1.1.3

Clinical evaluation of immunoassays

1.2

IMMUNITY IN CHILDHOOD

1.3

IMMUNITY IN PREGNANCY

1.4

IMMUNITY IN AGING

QUIZ

Chapter 2

IMMUNODEFICIENCY SYNDROMES

2.1

PRIMARY IMMUNODEFICIENCIES

2.1.1

T-cell and severe combined immunodeficiencies (SCID)

2.1.2

Immunodeficiencies associated with other major defects

2.1.3

X-linked agammaglobulinaemia (XLA)

2.1.4

Transient hypogammaglobulinaemia of infancy

2.1.5

Common variable immunodeficiency (CVID)

2.1.6

Selective immunoglobulin deficiencies

2.1.7

Hyper IgM syndrome

2.1.8

Lymphoprolipherative syndrome (Duncan's syndrom)

2.1.9

Phagocytic defects

2.1.10

Complement defects

2.1.11

Interferon and NK-cell defects

2.2

SECONDARY IMMUNODEFICIENCIES

2.2.1

AIDS

2.2.2

Malnutrition

2.2.3

Surgical intervention

2.2.4

Traumatic lesions

2.2.5

Loss of the immune organs

2.2.6

Polychemotherapy and radiotherapy

2.2.7

Chronic fatigue syndrome

2.2.8

Chronic stress

2.2.9

Professional and ecopathogenic factors

QUIZ

Chapter 3

IMMUNITY IN INFECTIOUS DISEASES

3.1

PATHOGENIC INFECTIONS

3.1.1

Resistance and immune responses depending
on a type of microbial parasitism

3.1.2

How pathogens can escape from the immune control

3.1.3

Immunity in bioterroristic infections and septic shock

3.2

OPPORTUNISTIC INFECTIONS

3.2.1

Mechanisms of reactivation of the opportunistic infections

3.2.2

Disorders of natural flora in mucosae

3.2.3

Recurrent pyogenic infections

3.2.4

Often respiratory tract infections

3.2.5

Herpes viruses infections

3.2.6

Mould infections

3.3

PROTOZOAN AND PARASITIC INVASIONS

3.4

PRION INFECTIONS

QUIZ

Chapter 4

ALLERGIC DISEASES

4.1

TYPES OF ALLERGIC PROCESSES

4.1.1

Mechanisms of allergic reactions

4.1.2

Allergological tests in vitro

4.2

ALLERGENS

4.2.1

Allergen kingdom

4.2.2

Allergen skin tests in vivo

4.2.3

Specific immunotherapy (SIT)

4.3

ATOPIC DISEASES

4.3.1

Allergic rhinitis

4.3.2

Bronchial asthma

4.3.3

Atopic dermatitis

4.3.4

Urticaria, Quinckeís odoema and drug allergy

4.3.5

Insect allergy and anaphylactic shock

4.4

CYTOTOXIC TYPE-BASED ALLERGIES

4.5

IMMUNE-COMPLEXES DISEASES

4.6

DELAYED TYPE-BASED ALLERGIES

4.7

PSEUDO-ALLERGIC REACTIONS

QUIZ

Chapter 5

AUTOIMMUNE DISEASES

5.1

TOLERANCE BREAKDOWN

5.2

ADDITIONAL RISK FACTORS AND MECHANISMS

5.2.1

Exogenous risk factors

5.2.2

Role of apoptosis disorders

5.2.3

Genetic risk factors

5.3

CLINICAL AUTOIMMUNITIES

5.3.1

Rheumatoid arthritis

5.3.2

Systemic lupus erythematosus

5.3.3

Thyroid diseases

5.3.4

Type 1 diabetes

5.3.5

Multiple sclerosis

QUIZ

Chapter 6

IMMUNITY IN CANCER

6.1

COMMON FEATURES OF CANCER CELLS

6.2

AVOIDANCE OF IMMUNE SURVEILANCE

6.2.1

Products of cancer cells

6.2.2

Fas counterattack in cancer

6.2.3

Cancer tolerance

6.3

IMMUNOTHERAPY FOR CANCER

QUIZ

Chapter 7

STRATEGIES FOR IMMUNOINTERVENTION

7.1

VACCINATION IN HISTORY AND TODAY

7.2

VACCINES AGAINST INFECTIONS

7.2.1

Attenuated and killed vaccines

7.2.2

Calendars of vaccination

7.3

VACCINES AGAINST NON-INFECTIOUS DISEASES

7.4

IMMUNOTHERAPY WITH DRUGS

7.4.1

Microbe-based preparations

7.4.2

Drugs derived from the immune organs

7.4.3

Interleukins and colony-stimulating factors

7.4.4

Interferons

7.4.5

Immunoglobulins

7.4.6

Monoclonal antibodies

7.4.7

Drugs derived from plants and moulds

7.4.8

Drugs derived from invertebrates

7.4.9

Synthetic drugs

7.5

TRANSPLANTATION

7.5.1

Mechanisms of the graft rejection

7.5.2

Graft-versus-host

7.5.3

Transplantation of the immune organs

7.5.4

Tissue cloning for transplantation

7.6

GENE THERAPY IN IMMUNE DISEASES

7.7

EXTRACORPORAL APPROACHES

QUIZ

The Third Part

REFERENCES

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© V.V. Klimov 2003